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991.
Primary torsion of the greater omentum: report of a case 总被引:1,自引:0,他引:1
Primary or idiopathic torsion of the greater omentum is an uncommon cause of acute abdominal pain, often mimicking other acute
abdominal conditions. The diagnosis is usually made at laparotomy, with the presence of free serosanguinous fluid in the absence
of any other intra-abdominal pathology being suggestive of this condition. Resection of the infarcted segment is the treatment
of choice, offering rapid recovery and reducing the possibility of adhesion formation. We report a case of primary omental
torsion and discuss the diagnostic and therapeutic implications of this entity.
Received: September 7, 2001 / Accepted: March 5, 2002 相似文献
992.
How significant is sensorineural hearing loss in primary Sjögren's syndrome? An individually matched case-control study 总被引:1,自引:0,他引:1
Boki KA Ioannidis JP Segas JV Maragkoudakis PV Petrou D Adamopoulos GK Moutsopoulos HM 《The Journal of rheumatology》2001,28(4):798-801
OBJECTIVE: We evaluated whether sensorineural loss and vestibular abnormalities are common in patients with primary Sj?gren's syndrome (pSS) and whether such abnormalities are clinically significant. METHODS: In an individually matched case-control design, 48 patients with pSS underwent complete audiovestibular evaluation along with 48 age and sex matched individuals without otologic problems. Differences of > 20 dB between patient and control ears at any frequency tested were considered to be significant. RESULTS: Significant differences in hearing loss were seen at 4,000 Hz (6 vs 0 ears; p = 0.03) and at 8,000 Hz (9 vs 0 ears; p = 0.003). Small differences in hearing acuity were also observed in the lower frequencies, but the absolute mean difference was < 3 dB. A decrease of at least 60 dB in hearing acuity at any frequency up to 4,000 Hz was seen only in 3 elderly pSS patients. Abnormal brainstem auditory evoked responses were recorded in 7 patients and 5 controls, but no patient had retrocochlear lesions identified on magnetic resonance imaging. Four patients in each group had abnormalities on electronystagmography. CONCLUSION: pSS is associated with sensorineural hearing loss affecting preferentially the high frequencies, but clinically significant defects are not common. There is no evidence of retrocochlear disease or increased vestibular involvement in pSS. 相似文献
993.
Papagelopoulos PJ Petrou HG Triantafyllidis PG Vlamis JA Psomas-Pasalis M Korres DS Stamos KG 《Orthopedics》2001,24(2):145-149
Fifty patients with an average age of 47 years received epidural steroid injections for lumbosacral radicular pain due to disk herniation or spinal stenosis. All patients had failed previous conservative treatment. Mean follow-up was 24 months (range: 12-36 months). Immediately after injection, all 50 patients reported various degrees of relief from leg and back pain. At the last follow-up examination, 68% of patients were asymptomatic, 20% had no change in preinjection radicular symptoms, and 12% had various degrees of relief. No significant correlation was found between pain relief, age, or number of injections. Early pain relief may be anticipated after epidural steroid injections in 80% of patients with radicular symptoms due to disk herniation or spinal stenosis. 相似文献
994.
Perimenis P Athanasopoulos A Gyftopoulos K Barbalias G 《International urology and nephrology》2001,32(4):609-613
Purpose: To evaluate conservative management of renal echinococcosis in cases with normal renal function and active disease. Patients and methods: From a series of 12 consecutive patients with primary renal echinococcosis, nephrectomy was suggested to 4 patients because
of kidney destruction. One patient who denied surgery and 5, in whom serological tests were positive, were given mebendazole
for 30 days. 3 patients with no evidence of active disease were not given any medication. Results: The patient who denied nephrectomy and 1 out of 5 with positive serological tests did not respond to mebendazole treatment.
The latter underwent a cyst excision. Thus, 4 responders to mebendazole and3 who were not given any medication, avoided surgery
and continue to have negative serological tests for more than 3 years. Conclusion: Conservative management and long term follow up are proposed for the non-active or mebendazole-responsive patients. For
the non-respondents or the cases with kidney destruction, surgery is the only hope for cure.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
995.
Hollow Porous Particles in Metered Dose Inhalers 总被引:5,自引:0,他引:5
Dellamary LA Tarara TE Smith DJ Woelk CH Adractas A Costello ML Gill H Weers JG 《Pharmaceutical research》2000,17(2):168-174
Purpose. To assess the physical stability and aerosol characteristicsof suspensions of hollow porous microspheres (PulmoSpheres) inHFA-134a.
Methods. Cromolyn sodium, albuterol sulfate, and formoterol fumaratemicrospheres were prepared by a spray-drying method. Particle sizeand morphology were determined via electron microscopy. Particleaggregation and suspension creaming times were assessed visually,and aerosol performance was determined via Andersen cascadeimpaction and dose uniformity studies.
Results. The hollow porous particle morphology allows the propellantto permeate freely within the particles creating a novel form ofsuspension termed a homodispersion, wherein the dispersed and continuousphases are identical, separated by an insoluble interfacial layer of drugand excipient. Homodispersion formation improves suspension stabilityby minimizing the difference in density between the particles andthe medium, and by reducing attractive forces between particles. Theimproved physical stability leads to excellent dose uniformity. Excellentaerosolization efficiencies are also observed with PulmoSpheresformulations, with fine particle fractions of about 70%.
Conclusions. The formation of hollow porous particles provides anew formulation technology for stabilizing suspensions of drugs inhydrofluoroalkane propellants with improved physical stability, contentuniformity, and aerosolization efficiency. 相似文献
996.
Nicolaidou P Nyktari G Georgouli H Athanassaki K Garoufi A Papadimitriou A Kavazarakis E Karpathios T 《Pediatric nephrology (Berlin, Germany)》2000,14(8-9):853-855
We measured plasma atrial natriuretic peptide (ANP) levels in 30 children with idiopathic hypercalciuria (IH) and 19 normal
controls (NC). A calcium (Ca) loading test was performed in all patients to determine the type of IH. Subsequently plasma
ANP, cAMP and renin activity (PRA), serum total and ionized Ca, intact parathyroid hormone, aldosterone, and 1,25-dihydroxyvitamin
D as well as urine Ca, cAMP, and electrolytes were determined in all subjects. The mean (SD) plasma ANP levels were significantly
lower in patients with renal hypercalciuria (RH) [21.4 (4.8) pg/ml] than in those with absorptive hypercalciuria (AH) [26.8
(7.6) pg/ml, P<0.05] and NC [27.6 (6.6) pg/ml, P<0.01]. PRA was significantly lower in AH [2.9 (1.3) ng/ml per hour] than in RH patients [7.8 (6.8) ng/ml per hour, P<0.01] and in NC [6.8 (4.6) ng/ml per hour, P<0.005]. Serum aldosterone values were significantly lower in AH [14.5 (11.4) ng/dl] than in RH patients [25.4 (14.1) ng/dl,
P<0.05] and in NC [32.6 (20.5), P<0.001]. The lower plasma ANP levels in RH than in AH patients and in NC may be due to Ca depletion. The lower PRA and serum
aldosterone levels in AH than in RH patients and in NC may be attributed to Ca excess.
Received: 18 November 1998 / Revised: 4 October 1999 / Accepted: 5 October 1999 相似文献
997.
Giannopoulou I Nakopoulou L Zervas A Lazaris AC Stravodimos C Giannopoulos A Davaris PS 《Urological research》2002,30(5):342-345
Apoptosis is a process which can retard the progress of malignant tumours. In the present study we investigated the immunohistochemical expression of three pro-apoptotic proteins (Bax, Fas receptor and caspase 3 - CPP32) as well as the apoptotic index (TUNEL Index) in 53 urothelial carcinomas of the urinary bladder. We examined all possible relationships between these factors and clinicopathological variables, as well as the patients' disease free survival. All three markers, and in particular the Fas receptor, were detectable in a remarkable proportion of specimens, however, none of the markers examined was associated with any clinicopathological parameter. In multivariate statistical analysis, Bax emerged as an independent predictor of a favourable prognosis. It is noteworthy that none of the pro-apoptotic markers examined was directly linked with the apoptotic rate of the malignant cells. 相似文献
998.
Konstas AG Nakos E Tersis I Lallos NA Leech JN Stewart WC 《American journal of ophthalmology》2002,133(6):753-757
PURPOSE: To evaluate morning vs evening once daily concomitant latanoprost 0.005%/timolol maleate 0.5% therapy in ocular hypertensive or primary open-angle glaucoma patients. DESIGN: Prospective single-center double-masked crossover comparison. METHODS: Patients who responded to timolol maleate 0.5% given twice daily were randomized to either evening or morning dosing of concomitant latanoprost 0.005% and timolol maleate 0.5% therapy for 7 weeks. Twenty-four hour diurnal curve intraocular pressure (IOP) testing was performed following each period. RESULTS: Thirty-six patients completed this study. There was a significant reduction at each time point in the 24-hour diurnal curve of both evening (17.1 +/- 2.7 mm Hg) and morning (17.3 +/- 3.1 mm Hg) dosed latanoprost/timolol maleate compared with timolol maleate given twice daily (21.1 +/- 3.3 mm Hg) (P <.0001). When the morning and evening dosing groups were compared directly, the 06:00 time point was statistically lower with evening dosing (16.4 +/- 2.3 mm Hg) vs morning dosing (17.9 +/- 2.8 mm Hg) (P =.01). Overall, a trend existed for greater daytime reduction with night-time dosing of the concomitant therapy, whereas morning dosing tended to give lower night-time pressures. There was a significantly lower mean range of diurnal pressure with evening (3.6 mm Hg) vs morning (4.3 mm Hg) dosing (P =.02). No differences in adverse events existed between the treated arms. CONCLUSIONS: This study suggests that latanoprost and timolol maleate, both given once daily in the morning or evening, effectively reduce the IOP for the 24-hour diurnal curve when compared with timolol maleate twice daily. 相似文献
999.
Ascorbic acid concentration is reduced in the aqueous humor of patients with exfoliation syndrome 总被引:3,自引:0,他引:3
Koliakos GG Konstas AG Schlötzer-Schrehardt U Bufidis T Georgiadis N Ringvold A 《American journal of ophthalmology》2002,134(6):879-883
PURPOSE: To investigate whether there is a role for ascorbic acid in the development of exfoliation syndrome (XFS). DESIGN: A case-control study was undertaken that included consecutive patients with and without XFS in whom cataract surgery was indicated. Patients with ophthalmic conditions other than XFS and conditions that may influence ascorbic acid levels were excluded. METHODS: A prospective institutional study was undertaken. A small volume of aqueous humor was aspirated at the beginning of phacoemulsification cataract surgery. Eighty aqueous samples, 40 samples from 40 eyes of 40 cataract patients with XFS and 40 samples from 40 eyes of 40 age matched cataract patients without XFS, were collected and analyzed. Ascorbic acid concentration was evaluated in the aqueous samples with a microplate assay method. RESULTS: The mean +/- SD concentration of ascorbic acid in the aqueous from patients with XFS (0.86 +/- 0.43 mM; range, 0.12 to 1.7 mM) was significantly lower than the concentration of ascorbic acid found in the aqueous of age-matched control patients (1.15 +/- 0.50 mM; range 0.42 to 3.1 mM; P =.0068). Total mean protein concentration was found to be significantly higher in the XFS group (481.1 +/- 196.8 pg/dl versus 336.3 +/- 86.4 pg/dl in the controls; P <.0001). Nevertheless, no correlation could be established between ascorbic level and protein concentration. CONCLUSIONS: A significantly reduced mean level of ascorbic acid was observed in the aqueous humor of patients with XFS. In view of the fact that ascorbic acid is a major protective factor against free radical action, a role for free radical action is possible in the pathobiology of XFS. 相似文献
1000.
Alexandros Polychronidis Prodromos Laftsidis Alexandra Giatromanolaki Sebachedin Perente Anastasios Bounovas Constantinos Simopoulos 《Gastric cancer》2008,11(1):59-63
Local recurrence at a gastrojejunal anastomosis is common in patients after gastrectomy for gastric carcinoma, but recurrence
at a jejunojejunal anastomosis without recurrence at a gastrojejunal anastomosis is extremely rare. We report a case of suture-line
recurrence at a jejunojejunal anastomosis without recurrence at the gastrojejunal anastomosis or in the remnant stomach in
a patient 23 months after receiving a Billroth II gastrectomy for gastric cancer. We attributed the implantation of cancer
cells at the jejunojejunal anastomosis to contamination of the stapler with cancer cells exfoliated in the gastric mucus during
the construction of the gastrojejunal anastomosis. We therefore consider that different surgical instruments, such as automatic
anastomotic devices and automatic suturing devices, must be used in each phase of the surgical procedure for gastric cancer. 相似文献